Jacque and Stevenson concluded that HIV-1 cDNA, upon entering the nucleus, must interact with emerin to contact chromatin, and they suggested that molecules that prevent this interaction might promote abortive HIV-1 infection of a cell. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. As a child, he had been limited in his participation in athletics in school. The arrangement of F-actin filaments impacts cell morphology, contractility and cell mechanics [ 84 ]. Single nuclei were cropped and subjected to 3D surface rendering followed by radial distance measurements of chromosome territories [ 8687 ]. Yorifuji, H.
Emerin is a protein that in humans is encoded by the EMD gene, also known as the STA gene. Contents. 1 Structure; 2 Function; 3 Clinical significance; 4 Interactions; 5 References; 6 Further reading; 7 External links.
Emerin. Gene Reviewed-Annotation score: Experimental evidence at protein leveli Legend: HelixTurnBeta strandPDB Structure known for this area. Emerin and several other LEM-domain proteins (e.g.
Haraguchi et al.
Emerin, LEM domain (IPR) < InterPro < EMBLEBI
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Emerin modulates spatial organization of chromosome territories in cells on softer matrices.
Ye Q, Worman HJ. Mutations in Emery-Dreifuss muscular dystrophy and their effects on emerin protein expression.
The structural hypothesis is based on the idea that lamin, along with other NE proteins. INM proteins bind to lamins to form a proteinaceous network called the nuclear lamina that is required for nuclear structure and function.
These emerin‐regulated cellular functions include regulating genomic architecture, maintaining nuclear structure and regulating gene.
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Characterization of the Drosophila melanogaster genome at the nuclear lamina. GWAS Central. Ellis, J.
Video: Emerin protein function and structure Protein Functions - Functions of protein - Science Land
Emerin has been shown to interact with:. Stochastic genome-nuclear lamina interactions: modulating roles of Lamin a and BAF.
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|The molecular architecture of lamins in somatic cells.
Ellis et al. Cartegni, L. Bank EM, Gruenbaum Y.
Video: Emerin protein function and structure NUCLEAR LAMINA
Using protein pull-down and coimmunoprecipitation assays, Libotte et al.