A novel laminin E8 cell adhesion site required for lung alveolar formation in vitro. An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions. Muscular dystrophy, congenital, due to ITGA7 deficiency. Integrins: emerging paradigms of signal transduction.
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha -7 integrin is critical for modulating cell-matrix interactions. . "Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and. The protein encoded by this gene belongs to the integrin alpha chain impairs the ability of Schwann cells to spread and to bind laminin.
Furthermore, the activation of alpha 7-X1 was cell type specific, and when expressed in HT cells, the integrin was converted into a fully functional receptor.
Nawrotzki, R. Please join your colleagues by making a donation now and again in the future.
Alpha7 integrin mediates cell adhesion and migration on specific laminin isoforms. Integrins: versatility, modulation, and signaling in cell adhesion.
OMIM Entry * INTEGRIN, ALPHA7 ITGA7
The function and distinctive regulation of the integrin VLA-3 in cell adhesion, spreading, and homotypic cell aggregation.
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Alternate splicing increases the structural diversity in the cytoplasmic domains of several integrin alpha and beta chains. Thus, ITGA7 represents an indispensable linkage between the muscle fiber and extracellular matrix that is independent of the dystrophin-dystroglycan complex-mediated interaction of the cytoskeleton with the muscle basement membrane.
Video: Integrin alpha 7 laminin cells Integrins in cancer - Mary Beckerle (Utah)
Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments.
The alpha-7 (ITGA7)/beta-1 (ITGB1; ) integrin is a specific cellular receptor for the basement membrane protein laminin-1 (see ), as well as for.
Mental retardation was also observed, and verbal abilities were limited to only a few words. June Gene Ontology.
Gene ResultITGA7 integrin subunit alpha 7 [ (human)]
Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development. Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains.
J Cell Biol.
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|Views Read Edit View history. Alternatively spliced forms of the Drosophila alphaPS2 subunit of integrin are sufficient for viability and can replace the function of the alphaPS1 subunit of integrin in the retina.
Video: Integrin alpha 7 laminin cells Integrin protein structure and signaling
Annu Rev Cell Dev Biol. External link. Inhibition of cell cycle progression by the alternatively spliced integrin beta 1C. Animal Model.